This paper explores the opportunities and limitations of forest thinning as a strategy to enhance the resistance and resilience of trees and forests to global change. The authors reviewed existing literature to assess how thinning impacts forest vulnerability to key stressors like drought, fire, insects and pathogens, and wind. While the study identifies several instances where thinning can be beneficial, particularly in mitigating drought and fire risks, it emphasizes that thinning is not a universal solution and its effectiveness varies depending on the specific stressor, forest type, and management practices. The paper highlights the need for more research, especially in underrepresented regions, to better understand the long-term effects of thinning and to develop effective adaptive forest management strategies in the face of increasing global environmental challenges.